Article
Molecular basis for the rhino Yurlovo (hr(rhY)) phenotype: severe skin abnormalities and female reproductive defects associated with an insertion in the hairless gene.
Experimental dermatology - 1 Oct 1998
Panteleyev A A, Ahmad W, Malashenko A M, Ignatieva E L, Paus R, Sundberg J P, Christiano A M
Abstract excerpt
In 1989, mice bearing mutations at the hr (hairless) locus were first proposed as a model for the human hair growth disorder papular atrichia, since in both these mice and in corresponding patients, a complete hair loss develops due to disintegration of the normal follicle structure into dermal cysts and so-called utriculi. Recently, the human hairless gene was characterized, and pathogenetic mutations were found...
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