Article
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance.
Science (New York, N.Y.) - 27 Nov 1998
Huang H, Chopra R, Verdine G L, Harrison S C
Abstract excerpt
A combinatorial disulfide cross-linking strategy was used to prepare a stalled complex of human immunodeficiency virus-type 1 (HIV-1) reverse transcriptase with a DNA template:primer and a deoxynucleoside triphosphate (dNTP), and the crystal structure of the complex was determined at a resolution...
Topics
- Anti-HIV Agents
- Binding Sites
- Catalytic Domain
- Crystallization
- Crystallography, X-Ray
- DNA Primers
- DNA, Viral
- Deoxyribonucleotides
- Dimerization
- Drug Resistance, Microbial
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Hydrogen Bonding
- Models, Molecular
- Mutation
- Nucleic Acid Conformation
- Protein Conformation