Relationship between number of ovulatory cycles and accumulation of mutant p53 in epithelial ovarian cancer.

doi:10.1093/jnci/90.22.1729

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Article

Relationship between number of ovulatory cycles and accumulation of mutant p53 in epithelial ovarian cancer.

Journal of the National Cancer Institute - 18 Nov 1998

Webb P M, Green A, Cummings M C, Purdie D M, Walsh M D, Chenevix-Trench G

Abstract excerpt

BACKGROUND: It has been suggested that increased numbers of ovulations might increase the risk of p53 gene (also known as TP53) mutation in the ovarian epithelium, thereby leading to the development of cancer. The data supporting this hypothesis have come from an observation that accumulation of...

Topics

Adult
Aged
Australia
Carcinoma
Case-Control Studies
Female
Humans
Middle Aged
Mutation
Neoplasm Invasiveness
Odds Ratio
Ovarian Neoplasms
Ovulation
Prevalence
Risk
Risk Factors
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 9827528
DOI: 10.1093/jnci/90.22.1729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9827528-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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