Article
Relationship between lifetime ovulatory cycles and overexpression of mutant p53 in epithelial ovarian cancer.
Journal of the National Cancer Institute - 2 Jul 1997
Schildkraut J M, Bastos E, Berchuck A
Abstract excerpt
BACKGROUND: Several lines of evidence have suggested a relationship between a woman's number of ovulatory cycles and the development of ovarian epithelial cancer. Repair of the ovarian surface after ovulation requires cellular proliferation, and spontaneous mutations arising during the DNA synthesis that accompanies this proliferation may play a role in carcinogenesis. PURPOSE: We conducted a molecular...
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