Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The basic helix-loop-helix leucine zipper transcription factor Mitf is conserved in Drosophila and functions in eye development.

Genetics - 1 May 2004

Hallsson Jón H, Haflidadóttir Benedikta S, Stivers Chad, Odenwald Ward, Arnheiter Heinz, Pignoni Francesca, Steingrímsson Eiríkur

Abstract excerpt

The MITF protein is a member of the MYC family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors and is most closely related to the TFE3, TFEC, and TFEB proteins. In the mouse, MITF is required for the development of several different cell types, including the retinal pigment epithelial (RPE) cells of the eye. In Mitf mutant mice, the presumptive RPE cells hyperproliferate, abnormally...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Conserved Sequence
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Genome

Share to Microphthalmia-Associated Transcription Factor

Share to Pigment Epithelium of Eye

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 15166150
DOI: 10.1534/genetics.167.1.233
PMCID: PMC1470875

Genes

MITF
RPE
MYC
TFEB
TFEC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The basic helix-loop-helix leucine zipper transcription factor Mitf is conserved in Drosophila and functions in eye development.PMID 15166150Read ↗

Role of Mitf in Differentiation and Transdifferentiation of Chicken Pigmented Epithelial CellSemantic proximity Read ↗

Microphthalmia-associated transcription factor (MITF): multiplicity in structure, function, and regulation.Semantic proximity Read ↗

Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF.Semantic proximity Read ↗

The Microphthalmia-Associated Transcription Factor (MITF) and Its Role in the Structure and Function of the Eye.Semantic proximity Read ↗

Beyond MITF: Multiple transcription factors directly regulate the cellular phenotype in melanocytes and melanoma.Semantic proximity Read ↗

MITF: a stream flowing for pigment cells.Semantic proximity Read ↗

Melanocytes and the microphthalmia transcription factor network.Semantic proximity Read ↗

A comprehensive series of temporal transcription factors in the fly visual systemSemantic proximity Read ↗

The novel mouse microphthalmia mutations Mitfmi-enu5 and Mitfmi-bcc2 produce dominant negative Mitf proteins.Semantic proximity Read ↗

Transient overexpression of the Microphthalmia gene in the eyes of Microphthalmia vitiligo mutant mice.Semantic proximity Read ↗

microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.Semantic proximity Read ↗

A mouse model of aniridia reveals the in vivo downstream targets of Pax6 driving iris and ciliary body development in the eye.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.