Article
Overexpression of p185erbB2/neu in the NbE prostatic epithelial cell line increases cellular spreading and the expression of integrin alpha6beta1.
International journal of oncology - 1 Dec 1998
Vafa A, Zhang Y, Sikes R A, Marengo S R
Abstract excerpt
Overexpression of p185erbB2/neu has been demonstrated in approximately 30% of prostatic carcinomas and has been shown to induce tumorigenesis and metastasis in a prostatic epithelial cell line, NbE. To metastasize successfully, cells must be able to proliferate, degrade and be motile on a variety...
Topics
- Analysis of Variance
- Cell Adhesion
- Cell Movement
- Epithelium
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- Integrin alpha6beta1
- Integrins
- Male
- Neoplasm Proteins
- Phenotype
- Prostatic Neoplasms
- Receptor, ErbB-2
- Tumor Cells, Cultured