Delivery of a constitutively active form of the heat shock factor using a virus vector protects neuronal cells from thermal or ischaemic stress but not from apoptosis.

doi:10.1046/j.1460-9568.1998.00339.x

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Article

Delivery of a constitutively active form of the heat shock factor using a virus vector protects neuronal cells from thermal or ischaemic stress but not from apoptosis.

The European journal of neuroscience - 1 Nov 1998

Wagstaff M J, Smith J, Collaco-Moraes Y, de Belleroche J S, Voellmy R, Coffin R S, Latchman D S

Abstract excerpt

The heat shock proteins (HSPs) are induced by stressful stimuli and have a protective effect. Different HSPs protect with different efficiencies against different stresses indicating that optimal protection would be obtained with a non-stressful agent which induced a range of HSPs. We have prepar...

Topics

Animals
Animals, Newborn
Apoptosis
Blotting, Western
Cell Line
DNA-Binding Proteins
Genetic Vectors
Heat Shock Transcription Factors
Heat-Shock Proteins
Hot Temperature
In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ischemia

Mice

Mutation

Neurons

Rats

Rats, Sprague-Dawley

Simplexvirus

Source

Open in PubMed

Identifiers

PMID: 9824447
DOI: 10.1046/j.1460-9568.1998.00339.x

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9824447-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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