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Article

Delivery of a constitutively active form of the heat shock factor using a virus vector protects neuronal cells from thermal or ischaemic stress but not from apoptosis.

The European journal of neuroscience - 1 Nov 1998

Wagstaff M J, Smith J, Collaco-Moraes Y, de Belleroche J S, Voellmy R, Coffin R S, Latchman D S

Abstract excerpt

The heat shock proteins (HSPs) are induced by stressful stimuli and have a protective effect. Different HSPs protect with different efficiencies against different stresses indicating that optimal protection would be obtained with a non-stressful agent which induced a range of HSPs. We have prepared a herpesvirus vector expressing a constitutively active mutant form of heat shock factor 1 (HSF1) which, unlike the...

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Source

Identifiers

PMID: 9824447
DOI: 10.1046/j.1460-9568.1998.00339.x

Genes

HSF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Delivery of a constitutively active form of the heat shock factor using a virus vector protects neuronal cells from thermal or ischaemic stress but not from apoptosis.PMID 9824447Read ↗

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