Article
Variation in the AU(AT)-rich element within the 3'-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians.
The Journal of clinical endocrinology and metabolism - 1 Nov 1998
Hegele R A, Harris S B, Zinman B, Wang J, Cao H, Hanley A J, Tsui L C, Scherer S W
Abstract excerpt
We are investigating associations between variations in candidate genes on chromosome 7q and diabetes-related phenotypes in Canadian Oji-Cree. One of these genes encodes the skeletal muscle regulatory G subunit of the glycogen-associated form of protein phosphatase 1 (PPPIR3), which may play a ke...
Topics
- 3' Untranslated Regions
- Alleles
- American Indian or Alaska Native
- Base Pairing
- Blood Glucose
- Chromosomes, Human, Pair 7
- Diabetes Mellitus, Type 2
- Genetic Variation
- Genotype
- Humans
- Ontario
- Phenotype
- Phosphoprotein Phosphatases
- Protein Phosphatase 1