Human lymphoblastoid CD4(+) T cells become permissive to macrophage-tropic strains of human immunodeficiency virus type 1 after passage into severe combined immunodeficient mice through in vivo upregulation of CCR5: in vivo dynamics of CD4(+) T-cell differentiation in pathogenesis of AIDS.

doi:10.1128/JVI.72.12.10323-10327.1998

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Article

Human lymphoblastoid CD4(+) T cells become permissive to macrophage-tropic strains of human immunodeficiency virus type 1 after passage into severe combined immunodeficient mice through in vivo upregulation of CCR5: in vivo dynamics of CD4(+) T-cell differentiation in pathogenesis of AIDS.

Journal of virology - 1 Dec 1998

Lapenta C, Parlato S, Spada M, Santini S M, Rizza P, Logozzi M, Proietti E, Belardelli F, Fais S

Abstract excerpt

In this article, we show that passage in SCID mice rendered a human CD4(+) T-cell line (CEM cells) highly susceptible to infection by macrophage-tropic (M-tropic) strains and primary clinical isolates of human immunodeficiency virus type 1 (HIV-1). This in vivo-acquired permissiveness of CEM cell...

Topics

Acquired Immunodeficiency Syndrome
Animals
Base Sequence
CD4-Positive T-Lymphocytes
Cell Differentiation
Cell Line
DNA Primers
Female
HIV-1
Humans

Leukocyte Common Antigens

Lymphocyte Activation

Macrophages

Mice

Mice, SCID

Phenotype

Protein Tyrosine Phosphatase, Non-Receptor Type 1

Receptors, CCR5

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