Multigene tracking of hepatitis C virus quasispecies after liver transplantation: correlation of genetic diversification in the envelope region with asymptomatic or mild disease patterns.

doi:10.1128/JVI.72.12.10036-10043.1998

Article

Multigene tracking of hepatitis C virus quasispecies after liver transplantation: correlation of genetic diversification in the envelope region with asymptomatic or mild disease patterns.

Journal of virology - 1 Dec 1998

Sullivan D G, Wilson J J, Carithers R L, Perkins J D, Gretch D R

Abstract excerpt

To investigate the role of hepatitis C virus (HCV) quasispecies mutation in the pathogenesis of HCV infection, we analyzed changes in the genetic diversity of HCV genomes in 22 patients before and after liver transplantation by using heteroduplex mobility assay (HMA) technology. All patients were...

Topics

Base Sequence
DNA Primers
Genes, env
Genetic Variation
Genome, Viral
Hepacivirus
Hepatitis C
Humans
Liver Transplantation
Mutation
Prognosis
Viral Nonstructural Proteins
Viremia

Multigene tracking of hepatitis C virus quasispecies after liver transplantation: correlation of genetic diversification in the envelope region with asymptomatic or mild disease patterns.

Abstract excerpt

Topics

Discuss the evidence