Article
Analysis of hepatitis C viral quasispecies in liver transplantation.
Transplantation proceedings - 1 Aug 2003
Moreno Garcia J, del Campo Terron S, Moraleda Garcia G, Garcia Gonzalez M, de Vicente Lopez E, Nuño Vazquez-Garza J, Fortun Abete J, Martin P, Barcena Marugan R
Abstract excerpt
The hepatitis C virus (HCV) is an RNA virus that replicates with a high rate of mutation, especially in the hypervariable region 1 (HVR-1). Continuous viral mutations lead to a mixed and changing populations of mutants, called quasispecies. The nature of the HCV quasispecies may have implications for viral persistence and pathogenies. Studies with liver transplant patients suggest a relationship between the...
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