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Article

Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2.

Journal of virology - 1 Dec 1998

Howe A Y, Jung J U, Desrosiers R C

Abstract excerpt

A truncated version of the nef gene of simian immunodeficiency virus SIVmac239 capable of encoding amino acids 98 to 263 was used as bait to screen a cDNA library from activated lymphocytes in a yeast two-hybrid system. The zeta chain of the T-cell receptor (TCRzeta) was found to interact specifically not only with truncated SIV nef in yeast cells but also with full-length glutathione S-transferase (GST)-SIVnef...

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Identifiers

PMID: 9811718
DOI: 10.1128/JVI.72.12.9827-9834.1998
PMCID: PMC110494

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