Article
Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2.
Journal of virology - 1 Dec 1998
Howe A Y, Jung J U, Desrosiers R C
Abstract excerpt
A truncated version of the nef gene of simian immunodeficiency virus SIVmac239 capable of encoding amino acids 98 to 263 was used as bait to screen a cDNA library from activated lymphocytes in a yeast two-hybrid system. The zeta chain of the T-cell receptor (TCRzeta) was found to interact specifi...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- DNA Primers
- Gene Products, nef
- Genes, nef
- HIV-1
- HIV-2
- Humans
- Jurkat Cells
- Membrane Proteins
- Molecular Sequence Data
- Peptide Fragments
- Protein-Tyrosine Kinases
- Receptors, Antigen, T-Cell