Cleavage of the murine leukemia virus transmembrane env protein by human immunodeficiency virus type 1 protease: transdominant inhibition by matrix mutations.

doi:10.1128/JVI.72.12.9621-9627.1998

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Article

Cleavage of the murine leukemia virus transmembrane env protein by human immunodeficiency virus type 1 protease: transdominant inhibition by matrix mutations.

Journal of virology - 1 Dec 1998

Kiernan R E, Freed E O

Abstract excerpt

We have identified mutations in the human immunodeficiency virus type 1 (HIV-1) matrix protein (MA) which block infectivity of virions pseudotyped with murine leukemia virus (MuLV) envelope (Env) glycoproteins without affecting infectivity conferred by HIV-1 Env or vesicular stomatitis virus G gl...

Topics

Animals
Cell Line
Gene Products, env
Genetic Vectors
HIV Protease
HIV-1
HeLa Cells
Humans
Leukemia Virus, Murine
Membrane Fusion
Mice
Mutation
Viral Matrix Proteins
Virulence

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