Article
Optimizing outcome after unrelated marrow transplantation by comprehensive matching of HLA class I and II alleles in the donor and recipient.
Blood - 15 Nov 1998
Petersdorf E W, Gooley T A, Anasetti C, Martin P J, Smith A G, Mickelson E M, Woolfrey A E, Hansen J A
Abstract excerpt
In unrelated marrow transplantation, the benefit of matching class II HLA-DRB1 and DQB1 alleles of the donor and recipient is well documented. Little is known about the clinical relevance of matching for class I HLA-A, B, and C alleles. We used DNA-amplification methods to identify the HLA-A, B, and C alleles of 300 patients and their donors. The incidence of graft failure was correlated with multiple class I...
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