p53 and p16/CDKN2 gene mutations in esophageal tumors from a high-incidence area in South Africa.

doi:10.1002/(sici)1097-0215(19981123)78:5<544::aid-ijc3>3.0.co;2-t

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Article

p53 and p16/CDKN2 gene mutations in esophageal tumors from a high-incidence area in South Africa.

International journal of cancer - 23 Nov 1998

Gamieldien W, Victor T C, Mugwanya D, Stepien A, Gelderblom W C, Marasas W F, Geiger D H, van Helden P D

Abstract excerpt

Squamous cell carcinoma of the esophagus has an uneven geographic distribution, with a high incidence in the Transkei region of Eastern Cape Province, South Africa. The precise molecular events associated with tumorigenesis of esophageal cancer in this region have not been characterized. DNA from...

Topics

Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell
Esophageal Neoplasms
Female
Gene Deletion
Genes, p16
Genes, p53
Humans
Male
Middle Aged
Mutation

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