Article
The isoenzyme-diagnostic regions of muscle-type creatine kinase, the M-260 and M-300 box, are not responsible for its binding to the myofibrillar M-band.
European journal of cell biology - 1 Sept 1998
Stolz M, Kraft T, Wallimann T
Abstract excerpt
Muscle-type creatine kinase is known for its unique interaction with the myofibrillar M-band, but the molecular origin for this structural relationship is not well understood. A systematic sequence comparison between the highly homologous cytosolic isoforms, muscle-type and brain-type creatine ki...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Chickens
- Creatine Kinase
- Cytosol
- Genetic Variation
- Isoelectric Focusing
- Isoenzymes
- Microscopy, Confocal
- Molecular Sequence Data
- Muscle, Skeletal
- Mutagenesis, Site-Directed
- Myofibrils
- Protein Binding
- Protein Conformation
- Rats
- Sequence Homology, Amino Acid