Enhanced induction of interleukin-12(p40) secretion by human macrophages infected with Mycobacterium avium complex isolates from disseminated infection in AIDS patients.

Abstract excerpt

Interleukin-12 (IL-12) is a key cytokine in the immune response to infection with Mycobacterium avium complex (MAC). Human immunodeficiency virus infection, a predisposing factor for disseminated MAC infection, causes a drop of bioactive IL-12(p70), mainly by decreasing the constitutive production of p35. IL-12(p40) and tumor necrosis factor-alpha (TNF-alpha) levels in supernatants of MAC-infected human...

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