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HIV‐1 Causes an Imbalance in the Production of Interleukin‐18 and Its Natural Antagonist in HIV‐Infected Individuals: Implications for Enhanced Viral Replication

15 Jan 2010

Abstract excerpt

BACKGROUND: Concentrations of interleukin (IL)-18 increase in the circulation of human immunodeficiency virus (HIV)-infected persons. However, nothing is known concerning the regulation of IL-18-binding protein (IL-18BP), which neutralizes IL-18 in vivo. This issue is addressed in the present study. METHODS: Serum samples obtained from healthy subjects and HIV-infected patients were analyzed by enzyme-linked...

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PMID: 20078197
DOI: 10.1086/650314

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