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Article

IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis.

FEMS immunology and medical microbiology - 1 Aug 2007

Pedra Joao H F, Tao Jian, Sutterwala Fayyaz S, Sukumaran Bindu, Berliner Nancy, Bockenstedt Linda K, Flavell Richard A, Yin Zhinan, Fikrig Erol

Abstract excerpt

Human anaplasmosis is an emerging infectious disease transmitted by ticks that can be potentially fatal in the immunocompromised and the elderly. The mechanisms of defense against the causative agent, Anaplasma phagocytophilum, are not completely understood; however, interferon (IFN)-gamma plays an important role in pathogen clearance. Here, we show that IFN-gamma is regulated through an early...

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PMID: 17521390
DOI: 10.1111/j.1574-695X.2007.00270.x

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Source receipt: pubmed, retrieved 7 Sept 2026.

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