Article
Retinal degeneration in the rd mouse in the absence of c-fos.
Investigative ophthalmology & visual science - 1 Nov 1998
Hafezi F, Abegg M, Grimm C, Wenzel A, Munz K, Stürmer J, Farber D B, Remé C E
Abstract excerpt
PURPOSE: Apoptosis is the final common death pathway of photoreceptors in light-induced retinal degeneration and in several animal models for retinal dystrophy. To date, little is known about gene regulation of apoptosis in the retina. The expression of the immediate early gene c-fos is upregulat...
Topics
- Animals
- Apoptosis
- DNA
- DNA Primers
- Female
- Gene Expression Regulation
- Genes, fos
- Genotype
- In Situ Nick-End Labeling
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Mutant Strains
- Photoreceptor Cells, Vertebrate
- Polymerase Chain Reaction
- Proto-Oncogene Proteins c-fos
- Retinal Degeneration
