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Article

Selection and characterization of mercury-independent activation mutants of the Tn501 transcriptional regulator, MerR.

Microbiology (Reading, England) - 1 Oct 1998

Parkhill Julian, Lawley Blair, Hobman Jonathan L, Brown Nigel L

Abstract excerpt

MerR is the transcriptional regulator of the mercury-resistance (mer) operon of transposon Tn501, acting at the mer promoter as both an activator in the presence of mercuric salts and a repressor in their absence. This paper reports a method for selection of constitutive activator mutants, which activate transcription in the absence of HgII, and the characterization of these MerRAC proteins. At least two...

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PMID: 9802027
DOI: 10.1099/00221287-144-10-2855

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Selection and characterization of mercury-independent activation mutants of the Tn501 transcriptional regulator, MerR.PMID 9802027Read ↗

Construction and characterization of a mercury-independent MerR activator (MerRAC): transcriptional activation in the absence of Hg(II) is accompanied by DNA distortion.Semantic proximity Read ↗

Site-specific insertion and deletion mutants in the mer promoter-operator region of Tn501; the nineteen base-pair spacer is essential for normal induction of the promoter by MerR.Semantic proximity Read ↗

Cd(II)-responsive and constitutive mutants implicate a novel domain in MerR.Semantic proximity Read ↗

Construction of a synthetic gene for the metalloregulatory protein MerR and analysis of regionally mutated proteins for transcriptional regulation.Semantic proximity Read ↗

The MerR metalloregulatory protein binds mercuric ion as a tricoordinate, metal-bridged dimer.Semantic proximity Read ↗

Overexpression of MerT, the mercuric ion transport protein of transposon Tn501, and genetic selection of mercury hypersensitivity mutations.Semantic proximity Read ↗

Purification and functional characterization of MerD. A coregulator of the mercury resistance operon in gram-negative bacteria.Semantic proximity Read ↗

Horizontal spread of mer operons among gram-positive bacteria in natural environments.Semantic proximity Read ↗

Mutations in the alpha and sigma-70 subunits of RNA polymerase affect expression of the mer operon.Semantic proximity Read ↗

The role of cysteine residues in the transport of mercuric ions by the Tn501 MerT and MerP mercury-resistance proteins.Semantic proximity Read ↗

Adaptation to mercury stress by nitrogen-fixing bacteria is driven by horizontal gene transfer and enhanced gene expression of the Mer operonSemantic proximity Read ↗

Mercury resistance (mer) operons in enterobacteria.Semantic proximity Read ↗

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