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Article

Imprinting of mouse Kvlqt1 is developmentally regulated.

Human molecular genetics - 1 Mar 1998

Gould T D, Pfeifer K

Abstract excerpt

Mouse distal chromosome 7 contains a cluster of at least five imprinted genes. The syntenic region in humans, at 11p15.5, has been implicated in several genetic disorders. Consistent with the imprinted status of the genes in the region, Beckwith-Wiedemann syndrome (BWS) and Wilms tumor are each associated with loss of maternal information. Also mapping to 11p15.5 are long QT and Jervell and Lange-Nielsen (JLN)...

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Identifiers

PMID: 9467008
DOI: 10.1093/hmg/7.3.483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Imprinting of mouse Kvlqt1 is developmentally regulated.PMID 9467008Read ↗

Strain-dependent developmental relaxation of imprinting of an endogenous mouse gene, Kvlqt1.Semantic proximity Read ↗

Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangementsSemantic proximity Read ↗

Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human.Semantic proximity Read ↗

Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1.Semantic proximity Read ↗

Multiple Mechanisms Regulate Imprinting of the Mouse Distal Chromosome 7 Gene ClusterSemantic proximity Read ↗

Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndromeSemantic proximity Read ↗

Loss of imprinting of a paternally expressed transcript, with antisense orientation to K <sub>V</sub> LQT1, occurs frequently in Beckwith–Wiedemann syndrome and is independent of insulin-like growth factor II imprintingSemantic proximity Read ↗

A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencerSemantic proximity Read ↗

Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprintingSemantic proximity Read ↗

Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.Semantic proximity Read ↗

Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Differential expression of KvLQT1 and its regulator IsK in mouse epitheliaSemantic proximity Read ↗

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