Article
Polymorphism in factor VII gene modifies phenotype of severe haemophilia.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 Nov 2009
Jayandharan G R, Nair S C, Poonnoose P M, Thomas R, John J, Keshav S K, Cherian R S, Devadarishini M, Lakshmi K M, Shaji R V, Viswabandya A, George B, Mathews V, Chandy M, Srivastava A
Abstract excerpt
The basis for 10-15% of patients with severe haemophilia having clinically mild disease is not fully understood. We hypothesized that polymorphisms in various coagulant factors may affect frequency of bleeding while functionally significant polymorphisms in inflammatory and immunoregulatory genes may also contribute to variations in the extent of joint damage. These variables were studied in patients with severe...
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