Article
Vitamin D receptor gene start codon polymorphisms (FokI) and bone mineral density: interaction with age, dietary calcium, and 3'-end region polymorphisms.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 1998
Ferrari S, Rizzoli R, Manen D, Slosman D, Bonjour J P
Abstract excerpt
Osteoporosis is a polygenic disease, whose determining loci have not yet been identified. Vitamin D receptor (VDR) gene polymorphisms in the 3'-end region (as determined by the enzymes BsmI and ApaI) have been inconsistently associated with bone mineral mass. More recently, VDR start codon polymo...
Topics
- Absorptiometry, Photon
- Adolescent
- Adult
- Age Factors
- Bone Density
- Calcium, Dietary
- Child
- Codon
- Deoxyribonucleases, Type II Site-Specific
- Female
- Femur Neck
- Genotype
- Humans
- Lumbar Vertebrae
- Middle Aged
- Polymorphism, Genetic
- Receptors, Calcitriol