Article
Vitamin D receptor gene start codon polymorphisms (FokI) and bone mineral density: interaction with age, dietary calcium, and 3'-end region polymorphisms.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 1998
Ferrari S, Rizzoli R, Manen D, Slosman D, Bonjour J P
Abstract excerpt
Osteoporosis is a polygenic disease, whose determining loci have not yet been identified. Vitamin D receptor (VDR) gene polymorphisms in the 3'-end region (as determined by the enzymes BsmI and ApaI) have been inconsistently associated with bone mineral mass. More recently, VDR start codon polymorphisms (as determined by the enzyme FokI) have been found to be related to adult bone mineral density (BMD) in pre-...
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