Article
Human primitive neuroectodermal tumour cells behave as multipotent neural precursors in response to FGF2.
Oncogene - 1 Oct 1998
Derrington E A, Dufay N, Rudkin B B, Belin M F
Abstract excerpt
Primitive neuroectodermal tumours (PNET) are thought to derive from the malignant transformation of pluripotent CNS precursors although this hypothesis has yet to be tested in vitro. Here we show that cells of a human PNET cell line 'Dev' express functional fibroblast growth factor (FGF) receptor...
Topics
- Biomarkers
- Cell Differentiation
- Cell Division
- Clone Cells
- Culture Media, Serum-Free
- Epithelial Cells
- Fibroblast Growth Factor 2
- Humans
- Neuroectodermal Tumors, Primitive
- Neurons
- Phenotype
- Receptors, Fibroblast Growth Factor
- Stem Cells
- Tumor Cells, Cultured