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Article

Human primitive neuroectodermal tumour cells behave as multipotent neural precursors in response to FGF2.

Oncogene - 1 Oct 1998

Derrington E A, Dufay N, Rudkin B B, Belin M F

Abstract excerpt

Primitive neuroectodermal tumours (PNET) are thought to derive from the malignant transformation of pluripotent CNS precursors although this hypothesis has yet to be tested in vitro. Here we show that cells of a human PNET cell line 'Dev' express functional fibroblast growth factor (FGF) receptors (FGFR) and respond to FGF2 as multipotent CNS precursors. FGF2 induces tyrosine phosphorylation of FGFR-1 and FGFR-2...

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Source

Identifiers

PMID: 9796695
DOI: 10.1038/sj.onc.1202025

Genes

FGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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