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Article

Existence of Neural Crest-Derived Progenitor Cells in Normal and Fuchs Endothelial Dystrophy Corneal Endothelium.

The American journal of pathology - 1 Oct 2016

Katikireddy Kishore Reddy, Schmedt Thore, Price Marianne O, Price Francis W, Jurkunas Ula V

Abstract excerpt

Human corneal endothelial cells are derived from neural crest and because of postmitotic arrest lack competence to repair cell loss from trauma, aging, and degenerative disorders such as Fuchs endothelial corneal dystrophy (FECD). Herein, we identified a rapidly proliferating subpopulation of cells from the corneal endothelium of adult normal and FECD donors that exhibited features of neural crest-derived...

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Source

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Identifiers

PMID: 27639969
DOI: 10.1016/j.ajpath.2016.06.011
PMCID: PMC5222986

Genes

NES
PAX3
PSIP1
SOX2
SOX9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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