Article
The association between HLA class I alleles and measles vaccine-induced antibody response: evidence of a significant association.
Vaccine - 1 Nov 1998
Poland G A, Jacobson R M, Schaid D, Moore S B, Jacobsen S J
Abstract excerpt
While the Moraten strain measles vaccine is an excellent, safe, and immunogenic vaccine, vaccine failure occurs, presumably when an individual develops an inadequate immune response. In this study, we examined the association of HLA class I genes and measles vaccine-induced antibody levels. We found that the allele distribution of HLA-B alleles differed between non-responders and hyper-responders (p = 0.002)....
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