Article
Nicotinamide-adenine dinucleotide phosphate oxidase assembly and activation in EBV-transformed B lymphoblastoid cell lines of normal and chronic granulomatous disease patients.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1998
Dusi S, Nadalini K A, Donini M, Zentilin L, Wientjes F B, Roos D, Giacca M, Rossi F
Abstract excerpt
This paper deals with the mechanisms of activation of NADPH oxidase investigated using EBV-transformed human B lymphoblastoid cell lines (B cells) from normal subjects and from patients affected by X-linked chronic granulomatous disease (CGD). The results reported are as follows. 1) In normal B cells, the NADPH oxidase components p67phox, p40phox, p22phox, and gp91phox were less expressed than in...
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