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Article

Properties and function of the P type ion pumps cloned from Helicobacter pylori.

Acta physiologica Scandinavica. Supplementum - 1 Aug 1998

Melchers K, Herrmann L, Mauch F, Bayle D, Heuermann D, Weitzenegger T, Schuhmacher A, Sachs G, Haas R, Bode G, Bensch K, Schäfer K P

Abstract excerpt

Three distinct P type pumps were cloned from H. pylori 69A. Two of these pumps, ATPase 439 and ATPase 948 (CopA), were isolated by gene library screening using DNA oligonucleotide primers. Amino acid similarities found for the predicted proteins were about 50% to Cd2+/Cu2+ pumps. Gene disruption mutagenesis rendered the H. pylori knockout mutants more sensitive to Zn2+ and Cd2+ (ATPase 439) or Cu2+ (CopA). Some...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 9789554

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