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Article

Structure-function relationships of the calcium binding sites of the sarcoplasmic reticulum Ca(2+)-ATPase.

Acta physiologica Scandinavica. Supplementum - 1 Aug 1998

Andersen J P, Vilsen B

Abstract excerpt

Site-directed mutagenesis studies of the structure and function of the Ca2+ binding sites of the sarcoplasmic reticulum Ca(2+)-ATPase are reviewed. The Ca2+ binding properties of six mutants with alterations to amino acid residues with oxygen-containing side chains in the membrane segments M4, M5, M6, and M8 were investigated. The mutations to Glu309 in M4, Glu771 in M5, Asn796, Thr799, and Asp800 in M6 all...

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PMID: 9789546

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