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Article

Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor

27 Oct 1998

Abstract excerpt

Exposure to cyclopamine, a steroid alkaloid that blocks Sonic hedgehog (Shh) signaling, promotes pancreatic expansion in embryonic chicks. Heterotopic development of pancreatic endocrine and exocrine structures occurs in regions adjacent to the pancreas including stomach and duodenum, and insulin-producing islets in the pancreas are enlarged. The homeodomain transcription factor PDX1, required for pancreas...

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PMID: 9789036
DOI: 10.1073/pnas.95.22.13036

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