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Article

Sonic hedgehog is required early in pancreatic islet development.

Developmental biology - 1 Apr 2002

diIorio Philip J, Moss Jennifer B, Sbrogna Jennifer L, Karlstrom Rolf O, Moss Larry G

Abstract excerpt

Pancreatic organogenesis relies on a complex interplay of cell-autonomous and extracellular signals. We demonstrate that the morphogen sonic hedgehog (Shh) is required for pancreatic development in zebrafish. Genetic mutants of Shh and its signaling pathway establish this dependence as specific to endocrine, but not exocrine, pancreas. Using cyclopamine to inhibit hedgehog signaling, we show that transient Shh...

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Identifiers

PMID: 11900460
DOI: 10.1006/dbio.2002.0573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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