Article
An MboI two-allele polymorphism may implicate the human renin gene in primary hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Sept 1998
Frossard P M, Lestringant G G, Elshahat Y I, John A, Obineche E N
Abstract excerpt
As a key enzyme of the renin-angiotensin-aldosterone system, the renin gene (REN) is a good candidate quantitative trait locus that may be implicated in the molecular etiology of essential hypertension. Among mixed reports on the subject, a REN MboI restriction fragment length polymorphism has been shown to be significantly associated with a family history of hypertension in a Japanese population. We show here...
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