Article
Decreased elastin gene expression in noncompliant human bladder tissue: a competitive reverse transcriptase-polymerase chain reaction analysis.
The Journal of urology - 1 Nov 1998
Djavan B, Lin V, Kaplan E P, Richier J C, Shariat S, Marberger M, McConnell J D
Abstract excerpt
PURPOSE: In low capacity noncompliant fibrotic bladders, as seen in patients with myelomeningocele, elevated storage pressures ultimately can lead to renal damage. Earlier studies have described an increased deposition of extracellular matrix protein, especially type III collagen, in the detrusor...
Topics
- Adolescent
- Child
- Child, Preschool
- Compliance
- Elastin
- Female
- Gene Expression Regulation
- Humans
- Male
- Mutation
- Prospective Studies
- Reverse Transcriptase Polymerase Chain Reaction
- Urinary Bladder
- Urinary Bladder Diseases
- Urodynamics