Mutation of the prion protein in Libyan Jews with Creutzfeldt-Jakob disease.

doi:10.1056/NEJM199104183241604

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Article

Mutation of the prion protein in Libyan Jews with Creutzfeldt-Jakob disease.

The New England journal of medicine - 18 Apr 1991

Hsiao K, Meiner Z, Kahana E, Cass C, Kahana I, Avrahami D, Scarlato G, Abramsky O, Prusiner S B, Gabizon R

Abstract excerpt

BACKGROUND: Creutzfeldt-Jakob disease is a transmissible neurodegenerative disorder that occurs more than 100 times more frequently among Libyan Jews than in the worldwide population. We examined 11 patients with the disease--10 Libyan Jews from Israel and 1 Libyan Jew from Italy--to determine whether abnormalities of the prion protein could be detected in them. Abnormal forms of this host-encoded protein are the...

Topics

Adult
Aged
Base Sequence
Codon
Creutzfeldt-Jakob Syndrome
Female
Gene Amplification
Humans
Israel
Italy
Jews
Libya

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Mutation

Open Reading Frames

Pedigree

Source

Open in PubMed

Identifiers

PMID: 2008182
DOI: 10.1056/NEJM199104183241604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2008182-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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