Article
Complete inhibition of SIVmac replication by its capsid mutants.
Virus genes - 1 Jan 1998
Shimano R, Inubushi R, Amano K, Ogasawara T, Akari H, Koyama A H, Kawamura M, Adachi A
Abstract excerpt
Mutations were introduced into a genomic region encoding the C-terminal portion of Gag capsid protein of pathogenic simian immunodeficiency virus (SIVmac239). All the mutants generated were defective for virion production and were non-infectious for monkey cells. They all efficiently suppressed the replication of wild type SIVmac in monkey cells. These results were in good agreement with those obtained for human...
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