Article
Complete inhibition of SIVmac replication by its capsid mutants.
Virus genes - 1 Jan 1998
Shimano R, Inubushi R, Amano K, Ogasawara T, Akari H, Koyama A H, Kawamura M, Adachi A
Abstract excerpt
Mutations were introduced into a genomic region encoding the C-terminal portion of Gag capsid protein of pathogenic simian immunodeficiency virus (SIVmac239). All the mutants generated were defective for virion production and were non-infectious for monkey cells. They all efficiently suppressed t...
Topics
- Animals
- Capsid
- Cell Line, Transformed
- Chloramphenicol O-Acetyltransferase
- DNA, Viral
- Defective Viruses
- Eukaryotic Cells
- HeLa Cells
- Humans
- Macaca mulatta
- Mutagenesis, Site-Directed
- Mutation
- RNA-Directed DNA Polymerase
- Simian Immunodeficiency Virus
- Virus Replication