Article
Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype.
Annals of neurology - 1 Sept 2000
Gibson G E, Haroutunian V, Zhang H, Park L C, Shi Q, Lesser M, Mohs R C, Sheu R K, Blass J P
Abstract excerpt
Brain metabolism and the activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), a mitochondrial enzyme, are diminished in brains from patients with Alzheimer's disease (AD). In 109 subjects, the Clinical Dementia Rating (CDR) score was highly correlated with brain KGDHC activity. In AD patients who carried the epsilon 4 allele of the apolipoprotein E gene (ApoE4), the CDR score correlated better with...
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