Article
Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: genetic and brain morphometric analyses.
Molecular psychiatry - 1 Sept 1998
Castellanos F X, Lau E, Tayebi N, Lee P, Long R E, Giedd J N, Sharp W, Marsh W L, Walter J M, Hamburger S D, Ginns E I, Rapoport J L, Sidransky E
Abstract excerpt
Although the etiology of attention-deficit/hyperactivity disorder (ADHD) is likely multifactorial, family, adoption, and twin studies suggest that genetic factors contribute significantly. Polymorphisms of the dopamine 4 receptor (DRD4) affect receptor binding, and one allele with seven tandem re...
Topics
- Alleles
- Attention Deficit Disorder with Hyperactivity
- Brain
- Child
- Child Behavior
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Parents
- Polymorphism, Genetic
- Receptors, Dopamine D2
- Receptors, Dopamine D4
- Reference Values