Article
Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: genetic and brain morphometric analyses.
Molecular psychiatry - 1 Sept 1998
Castellanos F X, Lau E, Tayebi N, Lee P, Long R E, Giedd J N, Sharp W, Marsh W L, Walter J M, Hamburger S D, Ginns E I, Rapoport J L, Sidransky E
Abstract excerpt
Although the etiology of attention-deficit/hyperactivity disorder (ADHD) is likely multifactorial, family, adoption, and twin studies suggest that genetic factors contribute significantly. Polymorphisms of the dopamine 4 receptor (DRD4) affect receptor binding, and one allele with seven tandem repeats in exon 3 (DRD4*7R) has been associated with ADHD. We examined this putative association in 41 children with...
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