Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest.

doi:10.1038/2464

Back to search

Article

Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest.

Nature genetics - 1 Oct 1998

Lefebvre L, Viville S, Barton S C, Ishino F, Keverne E B, Surani M A

Abstract excerpt

Mest (also known as Peg1), an imprinted gene expressed only from the paternal allele during development, was disrupted by gene targeting in embryonic stem (ES) cells. The targeted mutation is imprinted and reversibly silenced by passage through the female germ line. Paternal transmission activate...

Topics

Adult
Alleles
Animals
Female
Fetal Growth Retardation
Gene Targeting
Genomic Imprinting
Humans
Male
Maternal Behavior
Mice
Molecular Sequence Data
Pedigree
Phenotype
Proteins
RNA, Messenger

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.