Article
Hemoglobin Birmingham and hemoglobin Galicia: two unstable beta chain variants characterized by small deletions and insertions.
Blood - 1 May 1990
Wilson J B, Webber B B, Hu H, Kutlar A, Kutlar F, Codrington J F, Prchal J T, Hall K M, de Pablos J M, Rodriguez I
Abstract excerpt
Two unstable hemoglobins (Hbs) causing rather severe hemolytic anemia have been characterized. The beta chain of Hb Birmingham, found in an adult black man, is characterized by the loss of -Leu-Ala-His-Lys- at positions 141, 142, 143, and 144 and their replacement by one Gln residue. These change...
Topics
- Adult
- Amino Acid Sequence
- Base Sequence
- Chromatography, DEAE-Cellulose
- Chromosome Deletion
- DNA Transposable Elements
- Female
- Gene Amplification
- Genetic Variation
- Hemoglobins, Abnormal
- Humans
- Macromolecular Substances
- Male
- Molecular Sequence Data
- Peptide Fragments