Article
Two new human hemoglobin variants caused by unusual mutational events: Hb Zaïre contains a five residue repetition within the alpha-chain and Hb Duino has two residues substituted in the beta-chain.
Human genetics - 1 Aug 1992
Wajcman H, Blouquit Y, Vasseur C, Le Querrec A, Laniece M, Melevendi C, Rasore A, Galacteros F
Abstract excerpt
With rare exceptions, the more than 600 human hemoglobin variants described are caused by a single point mutation. Other abnormal features, such as unequal crossing-over, frameshift mutagenesis or double mutations in the same polypeptide chain, have seldom been encountered. We report two new vari...
Topics
- Adult
- Amino Acid Sequence
- Base Sequence
- Female
- Hemoglobins, Abnormal
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Pedigree