Article
Reassessing the role of region A in Pit1-mediated viral entry.
Journal of virology - 1 Aug 2002
Farrell Karen B, Russ Jill L, Murthy Ravi K, Eiden Maribeth V
Abstract excerpt
The mammalian gammaretroviruses gibbon ape leukemia virus (GALV) and feline leukemia virus subgroup B (FeLV-B) can use the same receptor, Pit1, to infect human cells. A highly polymorphic nine-residue sequence within Pit1, designated region A, has been proposed as the virus binding site, because mutations in this region abolish Pit1-mediated cellular infection by GALV and FeLV-B. However, a direct correlation...
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