Article
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein.
Journal of virology - 1 Nov 1998
Liang X H, Kleeman L K, Jiang H H, Gordon G, Goldman J E, Berry G, Herman B, Levine B
Abstract excerpt
bcl-2, the prototypic cellular antiapoptotic gene, decreases Sindbis virus replication and Sindbis virus-induced apoptosis in mouse brains, resulting in protection against lethal encephalitis. To investigate potential mechanisms by which Bcl-2 protects against central nervous system Sindbis virus...
Topics
- Alphavirus Infections
- Amino Acid Sequence
- Animals
- Antiviral Agents
- Apoptosis
- Apoptosis Regulatory Proteins
- Beclin-1
- Chromosomes, Human, Pair 17
- Encephalitis, Viral
- Female
- Genes, bcl-2
- Humans
- Male
- Membrane Proteins
- Mice
- Molecular Sequence Data