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Article

Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein.

Journal of virology - 1 Nov 1998

Liang X H, Kleeman L K, Jiang H H, Gordon G, Goldman J E, Berry G, Herman B, Levine B

Abstract excerpt

bcl-2, the prototypic cellular antiapoptotic gene, decreases Sindbis virus replication and Sindbis virus-induced apoptosis in mouse brains, resulting in protection against lethal encephalitis. To investigate potential mechanisms by which Bcl-2 protects against central nervous system Sindbis virus infection, we performed a yeast two-hybrid screen to identify Bcl-2-interacting gene products in an adult mouse brain...

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Identifiers

PMID: 9765397
DOI: 10.1128/JVI.72.11.8586-8596.1998
PMCID: PMC110269

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