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Article

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.

Cell - 23 Sept 2005

Pattingre Sophie, Tassa Amina, Qu Xueping, Garuti Rita, Liang Xiao Huan, Mizushima Noboru, Packer Milton, Schneider Michael D, Levine Beth

Abstract excerpt

Apoptosis and autophagy are both tightly regulated biological processes that play a central role in tissue homeostasis, development, and disease. The anti-apoptotic protein, Bcl-2, interacts with the evolutionarily conserved autophagy protein, Beclin 1. However, little is known about the functional significance of this interaction. Here, we show that wild-type Bcl-2 antiapoptotic proteins, but not Beclin 1...

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Identifiers

PMID: 16179260
DOI: 10.1016/j.cell.2005.07.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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