Article
Significance of ahpC promoter mutations for the prediction of isoniazid resistance in Mycobacterium tuberculosis.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Jul 1998
Rinder H, Thomschke A, Rüsch-Gerdes S, Bretzel G, Feldmann K, Rifai M, Löscher T
Abstract excerpt
To determine the value of ahpC promoter mutations for the rapid prediction of isoniazid resistance, this genomic region was characterized in 50 isoniazid-resistant and 12 isoniazid-sensitive Mycobacterium tuberculosis isolates. Of the resistant isolates, 12 had ahpC promoter mutations, but only o...
Topics
- Antitubercular Agents
- Bacterial Proteins
- Base Sequence
- Codon
- DNA, Bacterial
- Drug Resistance, Microbial
- Humans
- Isoniazid
- Molecular Sequence Data
- Mutation
- Mycobacterium tuberculosis
- Oxidoreductases
- Peroxidases
- Peroxiredoxins