Article
Significance of ahpC promoter mutations for the prediction of isoniazid resistance in Mycobacterium tuberculosis.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Jul 1998
Rinder H, Thomschke A, Rüsch-Gerdes S, Bretzel G, Feldmann K, Rifai M, Löscher T
Abstract excerpt
To determine the value of ahpC promoter mutations for the rapid prediction of isoniazid resistance, this genomic region was characterized in 50 isoniazid-resistant and 12 isoniazid-sensitive Mycobacterium tuberculosis isolates. Of the resistant isolates, 12 had ahpC promoter mutations, but only one possessed both an ahpC promoter mutation and a katG codon 315 substitution, although the latter was found in the...
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