The 5-HT1A agonist 8-OH-DPAT increases the number of spike-wave discharges in a genetic rat model of absence epilepsy.

doi:10.1016/s0006-8993(98)00801-4

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Article

The 5-HT1A agonist 8-OH-DPAT increases the number of spike-wave discharges in a genetic rat model of absence epilepsy.

Brain research - 5 Oct 1998

Gerber K, Filakovszky J, Halasz P, Bagdy G

Abstract excerpt

The effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) on the epileptiform activity has been investigated in adult WAG/RIJ rats. Either intraperitoneal (0.1-0.5 mg/kg) or intracerebroventricular (2-20 microg/rat) administration of 8-OH-DPAT caused marked, d...

Topics

8-Hydroxy-2-(di-n-propylamino)tetralin
Action Potentials
Animals
Disease Models, Animal
Dose-Response Relationship, Drug
Epilepsy, Absence
Genetic Predisposition to Disease
Injections, Intraperitoneal
Injections, Intraventricular
Piperazines
Rats
Rats, Inbred Strains
Serotonin Antagonists
Serotonin Receptor Agonists

Source

Open in PubMed

Identifiers

PMID: 9757054
DOI: 10.1016/s0006-8993(98)00801-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9757054-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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