Changes in enzyme activity and expression of DHFR of Toxoplasma gondii by antifolates.

doi:10.3347/kjp.1998.36.3.191

Back to search

Article

Changes in enzyme activity and expression of DHFR of Toxoplasma gondii by antifolates.

The Korean journal of parasitology - 1 Sept 1998

Baek E J, Nam H W

Abstract excerpt

The responses to antifolates of Toxoplasma gondii were investigated by measuring the dihydrofolate reductase (DHFR) activity, quantity of DHFR mRNA, and single-strand conformational polymorphism (SSCP) pattern. Pyrimethamine (PYM) and methotrexate (MTX) were tested as antifolates. When T. gondii...

Topics

Animals
Folic Acid Antagonists
Genome, Protozoan
Humans
Methotrexate
Mice
Mice, Inbred ICR
Mutation
Polymorphism, Single-Stranded Conformational
Pyrimethamine
RNA, Messenger
Reverse Transcriptase Polymerase Chain Reaction
Tetrahydrofolate Dehydrogenase
Toxoplasma
U937 Cells

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.