Article
sigmaR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2).
The EMBO journal - 1 Oct 1998
Paget M S, Kang J G, Roe J H, Buttner M J
Abstract excerpt
We have identified an RNA polymerase sigma factor, sigmaR, that is part of a system that senses and responds to thiol oxidation in the Gram-positive, antibiotic-producing bacterium Streptomyces coelicolor A3(2). Deletion of the gene (sigR) encoding sigmaR caused sensitivity to the thiol-specific...
Topics
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- Diamide
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Homeostasis
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Naphthoquinones
- Oxidative Stress
- Promoter Regions, Genetic
- Sigma Factor
- Signal Transduction
- Streptomyces
- Sulfhydryl Compounds
- Thioredoxin-Disulfide Reductase