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Article

sigmaR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2).

The EMBO journal - 1 Oct 1998

Paget M S, Kang J G, Roe J H, Buttner M J

Abstract excerpt

We have identified an RNA polymerase sigma factor, sigmaR, that is part of a system that senses and responds to thiol oxidation in the Gram-positive, antibiotic-producing bacterium Streptomyces coelicolor A3(2). Deletion of the gene (sigR) encoding sigmaR caused sensitivity to the thiol-specific oxidant diamide and to the redox cycling compounds menadione and plumbagin. This correlated with reduced levels of...

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Identifiers

PMID: 9755177
DOI: 10.1093/emboj/17.19.5776
PMCID: PMC1170905

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sigmaR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2).PMID 9755177Read ↗

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