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Article

Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003

Nakano Shunji, Küster-Schöck Elke, Grossman Alan D, Zuber Peter

Abstract excerpt

The Spx protein of Bacillus subtilis represses activator-stimulated transcription by interacting with the C-terminal domain of RNA polymerase (RNAP) alpha subunit. Its concentration increases in cells lacking the ATP-dependent protease, ClpXP, resulting in severe effects on growth and developmental processes. Microarray analysis was undertaken to identify genes that are induced or repressed when Spx interacts...

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Identifiers

PMID: 14597697
DOI: 10.1073/pnas.2235180100
PMCID: PMC263860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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