Article
Comparison of carcinoembryonic antigen promoter regions isolated from human colorectal carcinoma and normal adjacent mucosa to induce strong tumor-selective gene expression.
International journal of cancer - 5 Oct 1998
Cao G, Kuriyama S, Gao J, Mitoro A, Cui L, Nakatani T, Zhang X, Kikukawa M, Pan X, Fukui H, Qi Z
Abstract excerpt
To establish in vivo gene therapy against cancer, it is requisite to induce strong, cancer cell-selective expression of a therapeutic gene. Comparison of the promoter activity of 5' flanking regions of the carcinoembryonic antigen (CEA) gene isolated from various origins is therefore of considera...
Topics
- Base Sequence
- Carcinoembryonic Antigen
- Colorectal Neoplasms
- DNA
- DNA, Neoplasm
- Gene Expression
- Gene Expression Regulation, Neoplastic
- Genes, Reporter
- HeLa Cells
- Humans
- Intestinal Mucosa
- Luciferases
- Molecular Sequence Data
- Mutation