Article
Comparison of carcinoembryonic antigen promoter regions isolated from human colorectal carcinoma and normal adjacent mucosa to induce strong tumor-selective gene expression.
International journal of cancer - 5 Oct 1998
Cao G, Kuriyama S, Gao J, Mitoro A, Cui L, Nakatani T, Zhang X, Kikukawa M, Pan X, Fukui H, Qi Z
Abstract excerpt
To establish in vivo gene therapy against cancer, it is requisite to induce strong, cancer cell-selective expression of a therapeutic gene. Comparison of the promoter activity of 5' flanking regions of the carcinoembryonic antigen (CEA) gene isolated from various origins is therefore of considerable interest. The 5' flanking region of the CEA gene between -135 and +69 bp upstream from the transcriptional start...
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